Summer acquisitions Nicolas Jackson and Axel Disasi could make their debuts, but Christopher Nkunku, who arrived from RB Leipzig, could be out until January with a knee injury.
Wesley Fofana is out for the foreseeable future after undergoing knee surgery last month.
Benoit Badiashile, another defender, is out with a hamstring injury.
Mauricio Pochettino, the club’s new manager, has stated that Kepa Arrizabalaga will remain in goal ahead of newcomer Robert Sanchez.
Alexis MacAllister and Dominik Szoboszlai are ready to make their Liverpool debuts.
Thiago Alcantara and Stefan Bajcetic, two additional midfielders, are both out with injuries.
Chelsea and Liverpool have drawn the last six league and cup encounters, including the two domestic cup finals in 2022, both of which the Merseysiders won on penalties.
The four most recent meetings have all ended 0-0; no match in competitive English football history has ever ended goalless five times in a row.
Chelsea last played Liverpool in the first round of a top-flight season in 1937. George Mills scored a hat-trick as the Blues won 6-1.
Chelse Statistics
Since beating Borussia Dortmund 2-0 in the Champions League on March 7, the Londoners have gone winless in eight home games in all competitions
The Blues have won their first Premier League game 20 times, which is a joint record.
Chelsea has four Premier League wins and 20 points in 2023, fewer than any other team in the top level at the time.
They only won one of their 19 league games against opponents in the top half of the table last season, and it was away to Aston Villa in their penultimate game under Steven Gerrard.
The Blues made 139 changes to their starting eleven in the Premier League season 2022–23, the fourth most of any team.
Liverpool Statistics
Last season, Jurgen Klopp’s team lost eight Premier League away games, the same number as in the previous three seasons combined.
The Reds have not lost their first league game in any of the last ten seasons, with the last such defeat coming in 2012 against West Bromwich Albion.
Liverpool are unbeaten in 11 Premier League games
This streak began with a 0-0 tie at Chelsea, the only occasion they did not score in those 11 games.